Errr:
Junji Inanaga
at Kyushu University, in Japan, and colleagues recently explored chiral
rare earth metal complexes with fluorinated organophosphate ligands in
the enantioselective fluorination of β-ketoesters (Tet. Asym. 2006, 17,
504). "Previously published methods have been applied to bulky esters,"
Inanaga says, "while ours can be applied to popularly used small
esters, such as methyl ester." Using a scandium catalyst in combination
with a 1-fluoropyridinium triflate fluorinating reagent, the
researchers achieved yields as high as 94% with 84% enantiomeric excess
(ee).
Nope, I don’t know what it means either but sounds terribly sexy don’t it?
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